Experimental model for airway hyperreactivity
نویسندگان
چکیده
منابع مشابه
Eosinophil accumulation and airway hyperreactivity
On the basis of correlation studies, UNDERWOOD et al. [1] have concluded that accumulation and activation of eosinophils determines the hyperreactivity that results from an allergic reaction in guinea-pig airways. In justifying their policy of correlating responses at various intervals following an allergic reaction, they suggested that previous studies had used insufficient time points to perm...
متن کاملGold nanoparticles and airway hyperreactivity.
We were delighted to read the article in the European Respiratory Journal by HUSSAIN et al. [1] which demonstrated aggravation of pulmonary inflammation and airway hyperreactivity by gold (Au) nanoparticles (NPs) in a mouse model of chemical-induced asthma. Exposure of sensitised (but not unsensitised) mice to Au NPs was shown to result in increased airway resistance and reactivity to methachol...
متن کاملMechanisms of organophosphate insecticide-induced airway hyperreactivity.
It has been suggested that pesticide exposure may be a contributing factor underlying the increased incidence of asthma in the United States and other industrialized nations. To test this hypothesis, airway hyperreactivity was measured in guinea pigs exposed to chlorpyrifos, a widely used organophosphate pesticide. Electrical stimulation of the vagus nerves caused frequency-dependent bronchocon...
متن کاملCaveolin-1 knockout mice exhibit airway hyperreactivity.
Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding caveolin proteins. Although caveolins have been found in endothelium and epithelium (where they regulate nitric oxide synthase activity), their role in smooth muscle is still under investigation. We and others have previously shown that caveolae of human airway smooth muscle (ASM), which express caveolin-1, conta...
متن کاملAirway hyperreactivity in tropical pulmonary eosinophilia.
Eosinophils were recently proposed to act as prime inflammation-producing cells in asthma. Tissue eosinophil infiltration is an important feature of another disease, tropical pulmonary eosinophilia. Airway reactivity was determined in two patients with the latter disease and both were found to be hyperreactive.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58155-0